Imaging of Pdgfr Expression in Gliobalstoma Xenografts Using Affibody Molecule 111 In-dota-z09591

Postprint This is the accepted version of a paper published in Journal of Nuclear Medicine. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591. Access to the published version may require subscription. Disclosures: F.Y.F and P.J. are employees of Affibody AB. Affibody AB holds intellectual property for Affibody molecules. Academic partners have control of any data that might present a conflict of interest for employees or consultants. ABSTRACT Overexpression and excessive signaling of platelet derived growth factor receptor beta (PDGFR) has been detected in cancers, atherosclerosis, and in a variety of fibrotic diseases. Radionuclide in vivo visualization of PDGFR-expression might help to select PDGFR-targeting treatment for these diseases. The goal of this study was to evaluate the feasibility of in vivo radionuclide imaging of PDGFR-expression using an Affibody molecule, a small non-immunoglobulin affinity protein.